The Phospho-Smo (S616) Polyclonal Antibody (CABP0938) is specifically designed for research involving Smoothened (Smo), a key component of the Hedgehog signaling pathway. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunofluorescence.Smo is a transmembrane protein that plays a vital role in the regulation of developmental processes, cell differentiation, and tissue homeostasis. Phosphorylation of Smo at residue S616 has been shown to be critical for its activity and function in the Hedgehog signaling pathway.
This antibody binds specifically to phospho-Smo (S616), allowing for the detection and analysis of Smo phosphorylation in different cell types.Research into the Hedgehog signaling pathway and its components, such as Smo, is important for understanding various biological processes, including embryonic development, tissue regeneration, and cancer progression. The Phospho-Smo (S616) Polyclonal Antibody is a valuable tool for investigating the role of phosphorylated Smo in these processes, making it ideal for studies in developmental biology, cancer research, and regenerative medicine.
Product Name:
Phospho-SMO-S616 Rabbit Polyclonal Antibody
SKU:
CABP0938
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S616 of human SMO (NP_005622.1).
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
Purification Method:
Affinity purification
Gene ID:
6608
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Dot-blot analysis of all sorts of peptides using Phospho-SMO-S616 antibody (CABP0938) at 1:1000 dilution.Exposure time: 1s.
