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Anti-Phospho-NRF2-S40 Antibody (CABP1167)

SKU:
CABP1167
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
€139 - €489
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Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-Phospho-NRF2-S40 Antibody
Antibody SKU:CABP1167
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S40 of human NRF2
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding S40 of human NRF2
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4780
Uniprot:Q16236
Cellular Location:Cytoplasm, Nucleus, cytosol
Calculated MW:90kDa
Observed MW:65kDa
Anti-Phospho-NRF2-S40 Antibody (CABP1167)Western blot - Phospho-NRF2-S40 Rabbit pAb (CABP1167)
Synonyms:HEBP1, NRF2
Background:This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene.
UniProt Protein Function:NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: centrosome; cytoplasm; cytosol; nucleus; plasma membrane

Molecular Function:DNA binding; protein binding; protein domain specific binding; transcription factor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; transcription from RNA polymerase II promoter; unfolded protein response

NCBI Summary:This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
UniProt Code:Q16236
NCBI GenInfo Identifier:25453452
NCBI Gene ID:4780
NCBI Accession:Q16236.3
UniProt Secondary Accession:Q16236,Q53RW6, Q59HH2, Q96F71, B2RBU2, B4E338, E9PGJ7
UniProt Related Accession:Q16236
Molecular Weight:65,356 Da
NCBI Full Name:Nuclear factor erythroid 2-related factor 2
NCBI Synonym Full Names:nuclear factor, erythroid 2 like 2
NCBI Official Symbol:NFE2L2  
NCBI Official Synonym Symbols:NRF2; HEBP1  
NCBI Protein Information:nuclear factor erythroid 2-related factor 2
UniProt Protein Name:Nuclear factor erythroid 2-related factor 2
UniProt Synonym Protein Names:HEBP1; Nuclear factor, erythroid derived 2, like 2
UniProt Gene Name:NFE2L2  

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