Phosphothreonine Antibody is a rabbit polyclonal antibody directed against Phosphothreonine, offered by Assay Genie for research applications. Reported applications include WB, ICC/IF, IP and ELISA. Reactivity is species independent. Purified by Peptide Affinity.
Phosphothreonine is a phosphorylated derivative of threonine, catalyzed by serine/threonine kinases. It serves as a regulatory switch in numerous signaling pathways that govern neuronal survival, synaptic function, and stress responses. In the brain, phosphothreonine modifications influence the activity of key proteins such as tau, MAPKs, and transcription factors. Dysregulated threonine phosphorylation is associated with protein misfolding, impaired axonal transport, and neuroinflammation—hallmarks of neurodegenerative diseases. Notably, abnormal phosphorylation of tau at threonine residues contributes to its aggregation and toxicity in Alzheimer’s disease. As a modifiable and site-specific event, phosphothreonine is a valuable marker for disease progression and a potential target for kinase-based therapies in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, Biotin and FITC. Supplied in 400 µl. For research use only; not for diagnostic or therapeutic procedures.
