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Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-Piccolo Monoclonal Antibody, Clone 6H9-B6 (STMA00050). Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-Piccolo Monoclonal Antibody (STMA00050) at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT.
Key Features

Anti-Piccolo Antibody [6H9-B6]

Datasheet
SKU STMA00050
Antibody Type Monoclonal
Applications WB
Applications ICC/IF
Applications ELISA
Reactivity Human
Reactivity Mouse
Reactivity Rat
Host Species Mouse
Isotype IgG2b Kappa
$838

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Description

Piccolo Antibody [6H9-B6]

Piccolo Antibody [6H9-B6] is a mouse monoclonal antibody directed against Piccolo, offered by Assay Genie for research applications. Reported applications include WB, ICC/IF and ELISA. Reported reactivity: Human, Mouse and Rat. Supplied as IgG2b Kappa, purified by Protein G.

Piccolo (also known as Aczonin) is a large, multidomain scaffolding protein localized at the presynaptic active zone. It plays a central role in organizing the cytomatrix at active zones (CAZ) and coordinating synaptic vesicle trafficking, exocytosis, and endocytosis. Piccolo interacts with proteins involved in actin dynamics and clathrin-mediated endocytosis, including Abp1 and dynamin, thereby regulating synaptic vesicle recycling. It is often co-expressed with Bassoon, another CAZ protein, to maintain synaptic integrity and plasticity. Disruption of Piccolo expression or function has been linked to neurodevelopmental and neurodegenerative disorders, including schizophrenia and Parkinson’s disease. Its role in synaptic maintenance and plasticity makes Piccolo a promising target for understanding and treating synaptic dysfunction in neurological diseases. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.

Product Name:Piccolo Antibody [6H9-B6]
Product SKU:STMA00050
Size:100 µg
Target:Piccolo
Host Species:Mouse
Antibody Type:Monoclonal
Clone ID:6H9-B6
Research Areas:Neuroscience, Cell Markers, Neuron Markers, Presynaptic Markers
Buffer:PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:Liquid
Applications:WB, ICC/IF, ELISA
Antibody Isotype:IgG2b Kappa
Purification:Protein G Purified
Concentration:1 mg/ml
Reactivity:Human, Mouse, Rat
Recommended Dilution:WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Specificity:Detects ~550kDa. No cross-reactivity to Bassoon.
Guarantee:12 months from date of dispatch
Immunogen:Human full length recombinant protein (GenBank ID: BC001304.1)
Immunogen Species:Human
Accession Number:NP_001104266.1
Gene ID:26875
Swiss-Prot:Q9QYX7
Cellular Localization:Cell Junction | Synapse
Alternative Names:Protein piccolo, Aczonin, PCLO, Presynaptic cytomatrix protein, Multidomain presynaptic cytomatrix protein, Piccolo (presynaptic cytomatrix protein), PCLO_HUMAN, ACZ, Pico, Brain-derived HLMN protein, DKFZp779G1236, KIAA0559, Piccolo mouse homolog of Pico
References:1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619. 2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162. 3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038-6047.
Note:For research use only.
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