Anti-Podoplanin Antibody (CAB9242)

SKU:
CAB9242
€129 - €349

Description

Technical Manual

Anti-Podoplanin Antibody

Product Name:Anti-Podoplanin Antibody
Product SKU:CAB9242
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Immunogen:A synthesized peptide derived from human Podoplanin
Sequence:

Email for sequence

Gene ID:10630
Swiss Prot:Q86YL7
Synonyms:AGGRUS; GP36; GP40; Gp38; HT1A-1; OTS8; PA2.26; T1A; T1A-2; T1A2; TI1A
Calculated MW:36kDa
Observed MW:36KDa
Reactivity:Human, Mouse
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Application Key:Western blotting
Positive Samples:U2OS, U-87MG, Mouse lung
Cellular Location:

Product Images

Anti-Podoplanin Antibody (CAB9242)

Western blot - Podoplanin Rabbit mAb (CAB9242)

Uniprot Information

UniProt Protein Function:PDPN: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: external side of plasma membrane; filopodium; filopodium membrane; integral to plasma membrane; lamellipodium; microvillus membrane; plasma membrane; ruffle

Molecular Function:amino acid transmembrane transporter activity; folic acid transporter activity; water channel activity; water transporter activity

Biological Process: alveolus development; amino acid transport; cell morphogenesis; cell motility involved in cell locomotion; cell proliferation; cell-cell adhesion; folic acid transport; lung development; lymphangiogenesis; platelet activation; positive regulation of cell motility; prostaglandin metabolic process; regulation of cell shape; signal transduction; water transport

NCBI Summary:This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Code:Q86YL7
NCBI GenInfo Identifier:215274223
NCBI Gene ID:10630
NCBI Accession:Q86YL7.3
UniProt Secondary Accession:Q86YL7,O60836, O95128, Q7L375, Q8NBQ8, Q8NBR3, A9Z1Y2 B2R6J8, E9PB68, F6QWX5,
UniProt Related Accession:Q86YL7
Molecular Weight:12,421 Da
NCBI Full Name:Podoplanin
NCBI Synonym Full Names:podoplanin
NCBI Official Symbol:PDPN
NCBI Official Synonym Symbols:T1A; GP36; GP40; Gp38; OTS8; T1A2; TI1A; T1A-2; AGGRUS; HT1A-1; PA2.26
NCBI Protein Information:podoplanin
UniProt Protein Name:Podoplanin
UniProt Synonym Protein Names:Aggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1A
Protein Family:Podoplanin
UniProt Gene Name:PDPN
UniProt Entry Name:PDPN_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Cell Biology
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