Ponsegromab Antibody is a research-grade biosimilar monoclonal antibody targeting PLAB. It is a humanized IgG1-Kappa antibody. Reactivity: Human, Mouse. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% purity as determined by SDS-PAGE. For research use only.
Growth/differentiation factor 15 (GDF15/MIC1) is a ~34 kDa protein. Hormone produced in response to various stresses to confer information about those stresses to the brain, and trigger an aversive response, characterized by nausea, vomiting, and/or loss of appetite. The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future. Acts by binding to its receptor, GFRAL, activating GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes responses to stressful conditions. The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues.
Product Name:
Ponsegromab Antibody
SKU:
GXBS00704
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Clone:
Ponsegromab
Target:
PLAB
Isotype:
IgG1-Kappa
Host Species:
Human
Reactivity:
Human, Mouse
Applications:
ELISA, FCM, Functional assay, Research in vivo
Expression Host:
Mammalian cells
Synonyms:
PF-06946860, 2368950-15-4
Recommended Dilutions:
ELISA: 1:2000-1:20000
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only. Not suitable for clinical or therapeutic use.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
