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Anti-CYPOR Antibody (CAB5032)

SKU:
CAB5032
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CPR
CYPOR
P450R
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

Product Name:CYPOR Rabbit mAb
Product Code:CAB5032
Size:20uL, 50uL, 100uL
Synonyms:CPR, CYPOR, P450R
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human CYPOR
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, A-549, Mouse lung, Mouse liver, Mouse brain, Rat liver
Immunogen:A synthesized peptide derived from human CYPOR
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5447
Uniprot:P16435
Cellular Location:Endoplasmic reticulum membrane, Peripheral membrane protein
Calculated MW:77kDa
Observed MW:77kDa
UniProt Protein Function:POR: This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Defects in POR are the cause of Antley-Bixler syndrome with genital anomalies and disordered steroidogenesis (ABS1). A disease characterized by the association of Antley-Bixler syndrome with steroidogenesis defects and abnormal genitalia. Antley-Bixler syndrome is characterized by craniosynostosis, radiohumeral synostosis present from the perinatal period, midface hypoplasia, choanal stenosis or atresia, femoral bowing and multiple joint contractures. Defects in POR are the cause of disordered steroidogenesis due to cytochrome P450 oxidoreductase deficiency (DISPORD). A disorder resulting in a rare variant of congenital adrenal hyperplasia, with apparent combined P450C17 and P450C21 deficiency and accumulation of steroid metabolites. Affected girls are born with ambiguous genitalia, but their circulating androgens are low and virilization does not progress. Conversely, affected boys are sometimes born undermasculinized. Boys and girls can present with bone malformations, in some cases resembling the pattern seen in patients with Antley-Bixler syndrome.
UniProt Protein Details:

Protein type:EC 1.6.2.4; Endoplasmic reticulum; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 7q11.2

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; membrane

Molecular Function:[methionine synthase] reductase activity; NADPH-hemoprotein reductase activity; protein binding

Biological Process: positive regulation of monooxygenase activity; xenobiotic metabolic process

Disease: Antley-bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis; Antley-bixler Syndrome Without Genital Anomalies Or Disordered Steroidogenesis; Disordered Steroidogenesis Due To Cytochrome P450 Oxidoreductase Deficiency

NCBI Summary:This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
UniProt Code:P16435
NCBI GenInfo Identifier:2851393
NCBI Gene ID:5447
NCBI Accession:P16435.2
UniProt Related Accession:P16435
Molecular Weight:
NCBI Full Name:NADPH--cytochrome P450 reductase
NCBI Synonym Full Names:cytochrome p450 oxidoreductase
NCBI Official Symbol:POR  
NCBI Official Synonym Symbols:CPR; CYPOR; P450R  
NCBI Protein Information:NADPH--cytochrome P450 reductase
UniProt Protein Name:NADPH--cytochrome P450 reductase
Protein Family:Pyruvate synthase
UniProt Gene Name:POR  
UniProt Entry Name:NCPR_HUMAN

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