Povovetug Antibody is a research-grade biosimilar monoclonal antibody targeting NGF/Beta-NGF. It is a human IgG1, kappa antibody. Reactivity: Feline. Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry and functional assays. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Beta-nerve growth factor is a ~26 kDa protein. Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI.
Product Name:
Povovetug Antibody
SKU:
GXBS02682
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Beta-NGF
Isotype:
IgG1, kappa
Host Species:
Feline
Reactivity:
Feline
Applications:
ELISA, FCM, Functional assay
Synonyms:
CAS: 2975573-74-9
Recommended Dilutions:
ELISA: 1:2000-1:20000
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4.
State of Matter:
Liquid
Regulatory Status:
For research use only.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
