PPM1H Antibody [10D2] is a mouse monoclonal antibody directed against PPM1H, offered by Assay Genie for research applications. Reported applications include WB and ICC/IF. Reported reactivity: Human, Mouse and Rat. Supplied as IgG1, purified by Protein G.
PPM1H (Protein Phosphatase, Mg2+/Mn2+ Dependent 1H) is a serine/threonine phosphatase that modulates key signaling pathways in cellular homeostasis. It acts as a negative regulator of LRRK2 signaling by dephosphorylating Rab GTPases, which are critical for vesicle trafficking and lysosomal function. PPM1H has been identified as a gatekeeper of bone morphogenetic protein (BMP) signaling, preventing excessive activation through targeted dephosphorylation. It also serves as an independent prognostic biomarker in non-small cell lung cancer. In neuroscience, PPM1H’s regulation of Rab proteins and BMP pathways positions it as a potential modulator of neuroinflammation and synaptic integrity. Its role in maintaining vesicular transport and signaling balance makes it a candidate for therapeutic exploration in neurodegenerative diseases such as Parkinson’s. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.
Product Name:
PPM1H Antibody [10D2]
Product SKU:
STMA00221
Size:
100 µg
Target:
PPM1H
Host Species:
Mouse
Antibody Type:
Monoclonal
Clone ID:
10D2
Research Areas:
Neuroscience, Neurodegeneration, Parkinson's Disease, Cancer, Tumor Biomarkers, Oncoproteins, Signal Transducers, Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases
Buffer:
PBS pH7.4, 50% glycerol, 0.09% sodium azide
Storage & Shipping:
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, ICC/IF
Antibody Isotype:
IgG1
Purification:
Protein G Purified
Concentration:
1mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), ICC/IF (1:500); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~55kDa
Guarantee:
12 months from date of dispatch
Immunogen:
Recombinant Human PPM1H Protein
Immunogen Species:
Human
Accession Number:
NP_065751.1
Gene ID:
57460
Swiss-Prot:
Q9ULR3
Cellular Localization:
Intracellular
Tissue Specificity:
Parathyroid gland
Alternative Names:
Protein phosphatase Mg2+/Mn2+ dependent 1H, NERPP2C, Protein phosphatase 1H, PPM1H, KIAA1157
References:
1. Zhang W.Q., et al. (2021) Neoplasma. 68(5): 917-923. 2. Berndsen K., et al. (2019) 8:e50416. 3.Shen T., et al. (2014) Cell Res. 24(6): 727-741.
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