Description
PPP6R1 Antibody (PACO12025)
The PPP6R1 Polyclonal Antibody (PACO12025) is a valuable tool for researchers studying protein phosphatase 6 regulatory subunit 1 (PPP6R1) and its role in cellular signaling pathways. This antibody, derived from rabbit serum, has high specificity and sensitivity for detecting PPP6R1 in human samples, making it a reliable choice for Western blotting experiments.PPP6R1 is a key component of the protein phosphatase 6 (PP6) complex, which is involved in various cellular processes such as cell cycle regulation, DNA damage response, and stress signaling. Dysregulation of PPP6R1 has been linked to cancer development and progression, highlighting the importance of studying its function in disease.
By utilizing the PACO12025 antibody, researchers can investigate the expression levels and localization of PPP6R1 in different cell types and experimental conditions, providing valuable insights into its biological functions. This antibody is a valuable tool for studies in cancer biology, cell signaling, and drug development, paving the way for potential therapeutic interventions targeting PPP6R1-mediated pathways.
| Antibody Name: | PPP6R1 Antibody (PACO12025) |
| Antibody SKU: | PACO12025 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human SAPS1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SAPS domain family, member 1;SAPS1;KIAA1115;MGC138185;MGC142003;PP6R1;SAP190 ; |
| UniProt Protein Function: | SAPS1: Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Belongs to the SAPS family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 19q13.42 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; protein phosphatase binding Biological Process: COPII coating of Golgi vesicle; regulation of phosphoprotein phosphatase activity |
| NCBI Summary: | Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010] |
| UniProt Code: | Q9UPN7 |
| NCBI GenInfo Identifier: | 261260102 |
| NCBI Gene ID: | 22870 |
| NCBI Accession: | Q9UPN7.5 |
| UniProt Secondary Accession: | Q9UPN7,Q2M2H3, Q504V2, Q6NVJ6, Q9BU97, |
| UniProt Related Accession: | Q9UPN7 |
| Molecular Weight: | 96,724 Da |
| NCBI Full Name: | Serine/threonine-protein phosphatase 6 regulatory subunit 1 |
| NCBI Synonym Full Names: | protein phosphatase 6 regulatory subunit 1 |
| NCBI Official Symbol: | PPP6R1Â Â |
| NCBI Official Synonym Symbols: | PP6R1; SAPS1; SAP190; KIAA1115Â Â |
| NCBI Protein Information: | serine/threonine-protein phosphatase 6 regulatory subunit 1 |
| UniProt Protein Name: | Serine/threonine-protein phosphatase 6 regulatory subunit 1 |
| UniProt Synonym Protein Names: | SAPS domain family member 1 |
| Protein Family: | Serine/threonine-protein phosphatase |
| UniProt Gene Name: | PPP6R1Â Â |
| UniProt Entry Name: | PP6R1_HUMAN |
