| UniProt Protein Function: | PRIMPOL: DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH. Belongs to the eukaryotic-type primase small subunit family. Interacts with RPA1. 2 isoforms of the human protein are produced by alternative splicingProtein type: DNA repair, damage; DNA replication; MitochondrialChromosomal Location of Human Ortholog: 4q35.1Cellular Component: mitochondrial matrix; nucleusMolecular Function: chromatin binding; DNA primase activity; DNA-directed DNA polymerase activity; manganese ion binding; protein bindingBiological Process: bypass DNA synthesis; mitochondrial DNA replication; replication fork processing; response to UVDisease: Myopia 22, Autosomal Dominant |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96LW4 |
| NCBI GenInfo Identifier: | 663429539 |
| NCBI Gene ID: | 201973 |
| NCBI Accession: | NP_001287696.1 |
| UniProt Secondary Accession: | Q96LW4,Q5HYJ9, D3DP55, D6RDM1 |
| UniProt Related Accession: | Q96LW4 |
| Molecular Weight: | |
| NCBI Full Name: | DNA-directed primase/polymerase protein isoform 2 |
| NCBI Synonym Full Names: | primase and DNA directed polymerase |
| NCBI Official Symbol: | PRIMPOLÂ Â |
| NCBI Official Synonym Symbols: | MYP22; CCDC111Â Â |
| NCBI Protein Information: | DNA-directed primase/polymerase protein |
| UniProt Protein Name: | DNA-directed primase/polymerase protein |
| UniProt Synonym Protein Names: | Coiled-coil domain-containing protein 111 |
| Protein Family: | DNA-directed primase/polymerase protein |
| UniProt Gene Name: | PRIMPOLÂ Â |
| UniProt Entry Name: | PRIPO_HUMAN |
