| UniProt Protein Function: | PRMT5: an ubiquitous enzyme with protein methyltransferase activity. Methylates specific arginine residues in the transcription elongation factor SPT5, and the small nuclear ribonucleoproteins SNRPD1 and SNRPD3. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SPT5 transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Component of the methylosome, a 20S complex that includes ICLN, SKB1 and WDR77. Component of a high molecular weight E2F-pocket protein complex, CERC (cyclin E1 repressor complex). Also interacts with Sm proteins, JAK2, SSTR1 and SPT5. Associates with SWI/SNF remodeling complexes containing SMARCA2 and SMARCA4. |
| UniProt Protein Details: | Protein type:EC 2.1.1.125; Cell cycle regulation; Methyltransferase, protein arginine; RNA processing; Methyltransferase Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus Molecular Function:methyltransferase activity; ribonucleoprotein binding; protein binding; protein-arginine omega-N symmetric methyltransferase activity; histone-arginine N-methyltransferase activity; chromatin binding; transcription corepressor activity Biological Process: cell proliferation; peptidyl-arginine methylation, to symmetrical-dimethyl arginine; establishment and/or maintenance of chromatin architecture; peptidyl-arginine methylation; spliceosomal snRNP biogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of mitosis; gene expression; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; peptidyl-arginine N-methylation; endothelial cell activation |
| NCBI Summary: | This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015] |
| UniProt Code: | O14744 |
| NCBI GenInfo Identifier: | 32171585 |
| NCBI Gene ID: | 10419 |
| NCBI Accession: | O14744.4 |
| UniProt Related Accession: | O14744 |
| Molecular Weight: | |
| NCBI Full Name: | Protein arginine N-methyltransferase 5 |
| NCBI Synonym Full Names: | protein arginine methyltransferase 5 |
| NCBI Official Symbol: | PRMT5 |
| NCBI Official Synonym Symbols: | HSL7; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5 |
| NCBI Protein Information: | protein arginine N-methyltransferase 5 |
| UniProt Protein Name: | Protein arginine N-methyltransferase 5 |
| UniProt Synonym Protein Names: | 72 kDa ICln-binding protein; Histone-arginine N-methyltransferase PRMT5 (EC:2.1.1.125); Jak-binding protein 1; Shk1 kinase-binding protein 1 homolog; SKB1 homolog; SKB1Hs |
| UniProt Gene Name: | PRMT5 |
| UniProt Entry Name: | ANM5_HUMAN |
