| UniProt Protein Function: | PSMD14: a component of the 26S proteasome. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. |
| UniProt Protein Details: | Protein type:EC 3.4.19.-; Protease; Proteasome complex Chromosomal Location of Human Ortholog: 2q24.2 Cellular Component: cytosol; extracellular region; nucleoplasm; nucleus; proteasome complex Molecular Function:metallopeptidase activity; protein binding Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; neutrophil degranulation; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; transmembrane transport; tumor necrosis factor-mediated signaling pathway; ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway, planar cell polarity pathway |
| NCBI Summary: | This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012] |
| UniProt Code: | O00487 |
| NCBI GenInfo Identifier: | 51701716 |
| NCBI Gene ID: | 10213 |
| NCBI Accession: | O00487.1 |
| UniProt Secondary Accession: | O00487,O00176, B3KNW2, |
| UniProt Related Accession: | O00487 |
| Molecular Weight: | 35kDa |
| NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 14 |
| NCBI Synonym Full Names: | proteasome 26S subunit, non-ATPase 14 |
| NCBI Official Symbol: | PSMD14Â Â |
| NCBI Official Synonym Symbols: | PAD1; POH1; RPN11Â Â |
| NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 14 |
| UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 14 |
| UniProt Synonym Protein Names: | 26S proteasome regulatory subunit RPN11; 26S proteasome-associated PAD1 homolog 1 |
| UniProt Gene Name: | PSMD14Â Â |
