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Purified Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3513)

Datasheet MSDS
SKU AGEL3513
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Reactivity Mouse
Host Species Syrian Hamster
Isotype Syrian Hamster IgG
Clone 2F1
Conjugation Unconjugated
€25 - €63

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Description

system_update_altDatasheetsystem_update_altMSDS

Purified Anti-Human/Mouse KLRG-1 Antibody [2F1]

The Purified Anti-Human/Mouse KLRG-1 Antibody (2F1) available at assaygenie.com is a high-quality research tool designed for studying KLRG-1, a marker of T cell differentiation and exhaustion. This antibody, generated for both human and mouse samples, is produced for various applications in immunology research, including flow cytometry and immunohistochemistry.KLRG-1, a killer cell lectin-like receptor, serves as a valuable indicator of T cell differentiation states and functional properties. Its expression patterns are indicative of T cell exhaustion, senescence, or memory status, providing insights into immune response dynamics in various disease contexts.

By targeting KLRG-1, researchers can delve into the intricacies of T cell biology and its implications for conditions such as cancer, infections, and autoimmune diseases.This purified antibody, clone 2F1, offers specificity and sensitivity in detecting KLRG-1 expression levels, allowing for precise characterization and profiling of T cell populations. With its versatility and reliability, this antibody is an essential tool for advancing our understanding of T cell biology and immune response mechanisms in health and disease.

Product Title:Purified Anti-Human/Mouse KLRG-1 Antibody [2F1]
SKU:AGEL3513
Size:25µg, 100µg
Clone No:2F1
Synonyms:MAFA; 2F1-Ag;
Host Species:Syrian Hamster
Reactivity:Human;Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q96E93 O88713
Gene ID:10219,50928
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG2 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.
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