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Anti-QPCT Antibody (CAB6711)

SKU:
CAB6711
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 10 Anti-QPCT Antibody CAB6711
  • Cell Biology Antibodies 10 Anti-QPCT Antibody CAB6711
€139 - €419
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Description

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Antibody Name:Anti-QPCT Antibody
Antibody SKU:CAB6711
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:SW480, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAGG RHRR VVGT LHLL LLVA ALPW ASRG VSPS ASAW PEEK NYHQ PAIL NSSA LRQI AEGT SISE MWQN DLQP LLIE RYPG SPGS YAAR QHIM QRIQ RLQA DWVL EIDT FLSQ TPYG YRSF SNII STLN PTAK RHLV LACH YDSK YFSH WNNR VFVG ATDS AVPC AMML ELAR ALDK KLLS LKTV SDSK PDLS LQLI FFDG EEAF LHWS PQDS LYGS RHLA AKMA STPH PPGA RGTS QLHG MDLL VLLD LIGA PNPT FPNF FPNS ARWF ERLQ AIEH ELHE LGLL KDHS LEGR YFQN YSYG GVIQ DDHI PFLR RGVP VLHL IPSP FPEV WHTM DDNE ENLD ESTI DNLN KILQ VFVL EYLH L
Gene ID:25797
Uniprot:Q16769
Cellular Location:Secreted
Calculated MW:35kDa/40kDa
Observed MW:41kDa
Synonyms:QPCT, GCT, QC, sQC
Background:This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.
UniProt Protein Function:QPCT: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. Belongs to the glutaminyl-peptide cyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.3.2.5; Transferase; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p22.2

Molecular Function:glutaminyl-peptide cyclotransferase activity; zinc ion binding

Biological Process: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase; protein modification process

NCBI Summary:This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
UniProt Code:Q16769
NCBI GenInfo Identifier:2498824
NCBI Gene ID:25797
NCBI Accession:Q16769.1
UniProt Secondary Accession:Q16769,Q16770, Q3KRG6, Q53TR4,
UniProt Related Accession:Q16769
Molecular Weight:361
NCBI Full Name:Glutaminyl-peptide cyclotransferase
NCBI Synonym Full Names:glutaminyl-peptide cyclotransferase
NCBI Official Symbol:QPCT  
NCBI Official Synonym Symbols:QC; GCT; sQC  
NCBI Protein Information:glutaminyl-peptide cyclotransferase; EC; glutamyl cyclase; glutaminyl cyclase; glutaminyl-tRNA cyclotransferase
UniProt Protein Name:Glutaminyl-peptide cyclotransferase
UniProt Synonym Protein Names:Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC
UniProt Gene Name:QPCT  
UniProt Entry Name:QPCT_HUMAN
Anti-QPCT Antibody (CAB6711)Western blot analysis of extracts of various cell lines, using QPCT antibody (CAB6711) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s.
Anti-QPCT Antibody (CAB6711)Immunofluorescence analysis of MCF-7 cells using QPCT antibody (CAB6711). Blue: DAPI for nuclear staining.

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