Rab4 Antibody is a rabbit polyclonal antibody directed against Rab4, offered by Assay Genie for research applications. Reported applications include WB, IHC and ICC/IF. Reported reactivity: Human, Mouse and Rat. Purified by Peptide Affinity.
Rab4 is a 25 kDa GTPase of the Ras superfamily that regulates early endosomal recycling. It cycles between an inactive GDP-bound state and an active GTP-bound state, recruiting effector proteins to intracellular membranes. Rab4 modulates receptor recycling, including transferrin and glucose transporter (GLUT4) trafficking. Overexpression of Rab4 alters receptor distribution, leading to accumulation in post-endosomal compartments. Its activity is regulated by phosphorylation and post-translational lipid modifications, which influence membrane association and subcellular localization. In neurons, Rab4 is involved in synaptic vesicle recycling and receptor trafficking. Dysregulation of Rab4 may impair endosomal sorting and contribute to synaptic dysfunction in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µl. For research use only; not for diagnostic or therapeutic procedures.
Store at -20°C. Shipped on Blue Ice or 4°C. Conjugated variants should be stored according to the product label.
Format:
Liquid
Applications:
WB, IHC, ICC/IF
Purification:
Peptide Affinity Purified
Concentration:
1 mg/ml
Reactivity:
Human, Mouse, Rat
Recommended Dilution:
WB (1:1000), IHC (1:100), ICC/IF (1:150); optimal dilutions for assays should be determined by the user.
Specificity:
Detects ~26kDa.
Guarantee:
12 months from date of dispatch
Immunogen:
C-terminal peptide from human Rab4
Immunogen Species:
Human
Accession Number:
NP_004569.2
Gene ID:
5867
Swiss-Prot:
P20338
Cellular Localization:
Membrane | Cytoplasm
Alternative Names:
Oncogene Rab4, Rab4A, Ras related protein
References:
1. Stenmark H., and Olkkonen V.M. (2001) Genome Biol. 2: 3007.1-3007.7. 2. Takai Y., et al. (2001) Physiol. Rev. 8:, 153-208. 3. Ali B.R., et al. (2004) J. Cell Sci. 117: 6401-6412. 4. Zerial M., and McBride H. (2001) Nat. Rev. Mol. Cell Biol. 2: 107-117. 5. Cormont M., et al. (1996) Mol Cell Biology. 16: 6879-6886. 6. Ayad N., Hull M., and Mellman I. (1997) EMBO 16: 4497-4507. 7. Van der Sluijs, P. et l. (1992) The EMBO Journal 11(12), 4379-4389.
![Anti-Rab4 [R04-4F9] Monoclonal Antibody (AGMB02763)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/274052/676186/anti-rab4-r04-4f9-monoclonal-antibody-agmb02763__97863.1773028688.jpg?c=2 "Anti-Rab4 [R04-4F9] Monoclonal Antibody (AGMB02763)")
![Anti-Rab4 [R05-3K1] Monoclonal Antibody (AGMB03493)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/274782/680879/anti-rab4-r05-3k1-monoclonal-antibody-agmb03493__27983.1773043465.jpg?c=2 "Anti-Rab4 [R05-3K1] Monoclonal Antibody (AGMB03493)")
