Rafivirumab Antibody is a research-grade biosimilar monoclonal antibody targeting Glycoprotein. It is a canis IgG2a, kappa antibody. Reactivity: Rabies virus (RABV). Supplied as a liquid in 0.01M PBS pH 7.4. Applications: ELISA, flow cytometry, functional assays and in vivo research. Endotoxin: < 10 EU/mg. Purity: >95% as determined by SDS-PAGE. For research use only.
Glycoprotein (glycoprotein G) is a ~58 kDa protein. Attaches the virus to host cellular receptor, inducing endocytosis of the virion by using different host proteins including TFRC, GRM2 and ITGB1. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
Product Name:
Rafivirumab Antibody
SKU:
GXBS02637
Size:
100 µg, 1 mg
Antibody Type:
Monoclonal Antibody
Target:
Glycoprotein
Isotype:
IgG2a, kappa
Host Species:
Canine
Reactivity:
Rabies virus (RABV)
Applications:
ELISA, FACS, Functional assay, Research in vivo
Synonyms:
Glycoprotein, G
Purity:
>95% as determined by SDS-PAGE.
Endotoxin Level:
< 10 EU/mg
Formulation:
0.01M PBS pH 7.4
State of Matter:
Liquid
Regulatory Status:
For research use only.
Product Preparation:
Protein A/G purified from cell culture supernatant.
Storage and Handling:
Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
