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Anti-RALB Antibody (CAB4069)

SKU:
CAB4069
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
  • Cell Death Antibodies 2 Anti-RALB Antibody CAB4069
  • Cell Death Antibodies 2 Anti-RALB Antibody CAB4069
  • Cell Death Antibodies 2 Anti-RALB Antibody CAB4069
  • Cell Death Antibodies 2 Anti-RALB Antibody CAB4069
€139 - €419
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Description

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Antibody Name:Anti-RALB Antibody
Antibody SKU:CAB4069
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RALB (NP_002872.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:SKOV3, HepG2, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RALB (NP_002872.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAN KSKG QSSL ALHK VIMV GSGG VGKS ALTL QFMY DEFV EDYE PTKA DSYR KKVV LDGE EVQI DILD TAGQ EDYA AIRD NYFR SGEG FLLV FSIT EHES FTAT AEFR EQIL RVKA EEDK IPLL VVGN KSDL EERR QVPV EEAR SKAE EWGV QYVE TSAK TRAN VDKV FFDL MREI RTKK MSEN KDKN GKKS SKNK KSFK ERCC LL
Gene ID:5899
Uniprot:P11234
Cellular Location:Cell membrane, Cytoplasmic side, Lipid-anchor
Calculated MW:23kDa/25kDa
Observed MW:23kDa
Synonyms:RALB
Background:This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.
UniProt Protein Function:RALB: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis. Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.
UniProt Protein Details:

Protein type:G protein, monomeric, Ras; G protein; G protein, monomeric

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: plasma membrane; exocyst; autophagic vacuole; midbody

Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; ubiquitin protein ligase binding; ATPase binding

Biological Process: regulation of exocyst localization; positive regulation of protein binding; nerve growth factor receptor signaling pathway; apoptosis; metabolic process; regulation of exocyst assembly; Ras protein signal transduction; cytokinesis; positive regulation of protein amino acid phosphorylation; negative regulation of protein binding; signal transduction; cellular response to starvation

NCBI Summary:This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]
UniProt Code:P11234
NCBI GenInfo Identifier:131835
NCBI Gene ID:5899
NCBI Accession:P11234.1
UniProt Secondary Accession:P11234,Q53T32, Q6ZS74, B4E040,
UniProt Related Accession:P11234
Molecular Weight:206
NCBI Full Name:Ras-related protein Ral-B
NCBI Synonym Full Names:v-ral simian leukemia viral oncogene homolog B
NCBI Official Symbol:RALB  
NCBI Protein Information:ras-related protein Ral-B; RAS-like protein B; ras related GTP binding protein B; v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
UniProt Protein Name:Ras-related protein Ral-B
Protein Family:Ras-related protein
UniProt Gene Name:RALB  
UniProt Entry Name:RALB_HUMAN
Anti-RALB Antibody (CAB4069)Western blot analysis of extracts of various cell lines, using RALB antibody (CAB4069) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-RALB Antibody (CAB4069)Immunohistochemistry of paraffin-embedded human liver damage using RALB antibody (CAB4069) at dilution of 1:100 (40x lens).
Anti-RALB Antibody (CAB4069)Immunohistochemistry of paraffin-embedded human colon carcinoma using RALB antibody (CAB4069) at dilution of 1:100 (40x lens).
Anti-RALB Antibody (CAB4069)Immunohistochemistry of paraffin-embedded human gastric cancer using RALB antibody (CAB4069) at dilution of 1:100 (40x lens).

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