Rat CD25 monoclonal antibody (FITC) (AGIM0280)
- SKU:
- AGIM0280
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Rat
- Host Species:
- Mouse
- Isotype:
- IgG1
- Clone:
- MRC OX-39
- Conjugation:
- FITC
- Applications:
- FC
Description
| Product Name: | Rat CD25 monoclonal antibody (FITC) |
| Product Code: | AGIM0280 |
| Size: | 500 µL |
| Reactivity: | Rat |
| Clone: | MRC OX-39 |
| Applications: | Flow Cytometry |
| Conjugate: | FITC |
| Isotype: | IgG1 |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light |
| Uniprot: | P26897 |
| UniProt Protein Function: | IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10p15-p14 Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane Molecular Function:interleukin-2 receptor activity; drug binding; interleukin-2 binding Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; apoptosis; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; cell proliferation; negative regulation of T cell proliferation; inflammatory response to antigenic stimulus; cell surface receptor linked signal transduction; positive regulation of T cell differentiation; negative regulation of inflammatory response; immune response; inflammatory response; activated T cell apoptosis Disease: Interleukin 2 Receptor, Alpha, Deficiency Of; Diabetes Mellitus, Insulin-dependent, 10 |
| NCBI Summary: | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009] |
| UniProt Code: | P26897 |
| NCBI GenInfo Identifier: | 4557667 |
| NCBI Gene ID: | 3559 |
| NCBI Accession: | NP_000408.1 |
| UniProt Secondary Accession: | P26897,P26897, |
| UniProt Related Accession: | P01589 |
| Molecular Weight: | 30,819 Da |
| NCBI Full Name: | interleukin-2 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 2 receptor, alpha |
| NCBI Official Symbol: | IL2RAÂ Â |
| NCBI Official Synonym Symbols: | CD25; IL2R; TCGFR; IDDM10Â Â |
| NCBI Protein Information: | interleukin-2 receptor subunit alpha; p55; IL2-RA; IL-2-RA; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-2 receptor subunit alpha |
| UniProt Synonym Protein Names: | TAC antigen; p55 |
| UniProt Gene Name: | IL2RAÂ Â |
| UniProt Entry Name: | IL2RA_HUMAN |
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