Recombinant 2019-nCoV Methyltransferase / ME Protein (His Tag) (RPES0058)
Coronavirus encodes the 2'-O-MTase（2'O Methyltransferase） that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design in an expanding Coronavirus outbreak setting, such as COVID-19. Targeting on the 2'O-methylation pathway on SARS-CoV replication and pathogenesis can be the treatment options for vaccine and anti-viral durgs development which can against SARS-CoV-2，SARS-CoV, MERS-CoV or other RNA and DNA viruses.
Product Name:
Recombinant 2019-nCoV Methyltransferase / ME Protein (His Tag)
SKU:
RPES0058
Size:
100µg
Species:
Virus
Sequence:
Ser6799-Asn7096
Accession:
YP_009724390.1
Purity:
> 85 % as determined by reducing SDS-PAGE.
Endotoxin:
< 1.0 EU per µg as determined by the LAL method.
Formulation:
Lyophilized from sterile 20 mM Tris 150 mM NaCl, pH 8.3.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
