The Recombinant ADA Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C331658) against ADA. Adenosine deaminase (ADA) catalyzes adenosine degradation. Lack of this enzyme leads to the accumulation of toxic metabolites causing severe combined immunodeficiency (ADA-SCID), an autosomal recessive disorder. Differentiation and function of T cells, B cells, and natural killer cells are impaired in ADA-SCID patients leading to recurrent infections. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB applications. It has been validated by WB analysis of MOLT-4,?Jurkat. The target is localized to the cytoplasm, lysosome, Cell Membrane, cell junction.
