The Recombinant AMACR Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C321038) against AMACR. Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters. Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl) propionic acid) but neither 3-methyl-branched nor linear-chain acyl-CoAs. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of U2-OS (Low expression), LNCaP, Caco-2, Human liver and IHC analysis of Human kidney, Human liver. The target is localized to the peroxisome, mitochondrion.