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Recombinant CD33 Monoclonal Antibody (AGEL6404)

Datasheet MSDS
SKU AGEL6404
Product Type Antibody
Reactivity Human
Applications IHC
Host Species Rabbit
Clonality Monoclonal
Clone C351098
Conjugate Unconjugated
$606 - $843

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Description

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Recombinant CD33 Monoclonal Antibody

The Recombinant CD33 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C351098) against CD33. Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for IHC applications. It has been validated by IHC analysis of Human lymphoma, Human spleen. The target is localized to the membrane.

Product Name:Recombinant CD33 Monoclonal Antibody
SKU:AGEL6404
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:CD33, CD33 molecule, gp67, Myeloid cell surface antigen CD33, p67, Sialic acid-binding Ig-like lectin 3, SIGLEC-3, SIGLEC3
Reactivity:Human
Immunogen:Recombinant human CD33 fragment
Applications:IHC
Clonality:Recombinant Monoclonal
Clone No:C351098
Host:Rabbit
Isotype:Rabbit IgG
Target:CD33
Conjugation:Unconjugated
Recommended Dilution:IHC 1:200-1000
UniProt:P20138
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
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