100% Quality Guarantee
PhD-Level Technical Support
Key Features

Recombinant CDKN2A/p16INK4a Monoclonal Antibody (AGEL6917)

Datasheet MSDS
SKU AGEL6917
Product Type Antibody
Reactivity Human
Applications WB, IHC
Host Species Rabbit
Clonality Monoclonal
Clone C321612
Conjugate Unconjugated
€459 - €639

Request a formal quotation

A PDF quote with its own quote number, ready for your purchasing office to raise a PO against. Back within 4 working hours, from a PhD scientist — not an autoresponder.

  • PO-ready PDFQuote number, VAT, Incoterms
  • Volume pricing appliedDiscounts from 2 kits up
  • Valid 30 daysPrices held while you get sign-off
Anything we should know? optional

No account needed. We use your details only to prepare and send this quote. If it's urgent, say so in the box and we'll come back the same working day.
Global Shipping: 80+ Countries
White Glove Service: Available upon request
Batch Consistency: Contact Sales
Distributors: 60+ Countries
Contact Sales Quote or discount
Find Distributor 50+ countries
Technical Support PhD-level team
Live Chat Available now

Description

system_update_altDatasheetsystem_update_altMSDS

Recombinant CDKN2A/p16INK4a Monoclonal Antibody

The Recombinant CDKN2A/p16INK4a Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C321612) against CDKN2A/p16INK4a. Members of the INK4 family of cyclin dependent kinase inhibitors include p16 INK4A, p15 INK4B, p18 INK4C, and p19 INK4D. The INK4 family members inhibit cyclin dependent kinases 4 and 6 (CDK4 and CDK6), causing cell cycle arrest in G1 phase. The INK4A-ARF-INK4B locus on chromosome 9p21, frequently lost in human cancer, encodes the INK4 family members p16 INK5A and p15 INK4B, as well as the unrelated protein, ARF.p16 INK4A expression, typically repressed in the absence of stress, is thought to drive cells into senescence, and p16 INK4A expression is a commonly used marker of senescent cells. p16 INK4A protein expression is often altered in human cancer, and high expression is currently used as a predictive biomarker in cervical cancer. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.

This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of MCF-7 (Negative control), HeLa, HEK-293 and IHC analysis of Human cervical cancer. The target is localized to the cytoplasm, nucleus.

Product Name:Recombinant CDKN2A/p16INK4a Monoclonal Antibody
SKU:AGEL6917
Size:50 µL, 100 µL
Antibody Type:Recombinant Monoclonal Antibody
Synonyms:ARF, CCM2, CDK4 inhibitor p16 INK4, CDK4I, CDKN, CDKN2, CDKN2A, Cell cycle negative regulator beta, CMM, CMM2, Cyclin dependent kinase 4 inhibitor A, Cyclin Dependent Kinase Inhibitor 2A, Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4), Cyclin dependent kinase inhibitor 2A isoform 4, Cyclin dependent kinase inhibitor 2A isoforms 1/2/3, Cyclin dependent kinase inhibitor p16, Cyclin-dependent kinase inhibitor 2A, INK, INK4, INK4A, MLM, MTS, MTS-1, MTS1, Multiple tumor suppressor 1, P14, P14ARF, P16, P16-INK4A, P16INK, P16INK4, P16INK4A, P19, P19ARF, TP16
Reactivity:Human
Immunogen:Peptide. This information is proprietary to PTMab.
Applications:WBIHC
Clonality:Recombinant Monoclonal
Clone No:C321612
Host:Rabbit
Isotype:Rabbit IgG
Target:CDKN2A/p16INK4a
Conjugation:Unconjugated
Observed MW:16 kDa
Calculated MW:17 kDa
Recommended Dilution:WB 1:5000-10000; IHC 1:50-100
UniProt:P42771
Purification:Protein A
Concentration:1 mg/mL
Buffer:PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Storage:Store at -20°C valid for 12 months. Avoid freeze / thaw cycles.
View AllClose

0 Reviews

Write a Review
0
Based on 0 reviews

No reviews yet. Be the first to share your experience!

View AllClose

Related Products