The Recombinant EAAT3 Monoclonal Antibody is a recombinant rabbit monoclonal antibody (clone C321630) against EAAT3. During neurotransmission, glutamate is released from vesicles of the presynaptic cell, and glutamate receptors (e.g., NMDA Receptor, AMPA Receptor) bind glutamate for activation at the opposing postsynaptic cell. Excitatory amino acid transporters (EAATs) regulate and maintain extracellular glutamate concentrations below excitotoxic levels. In addition, glutamate transporters may limit the duration of synaptic excitation by an electrogenic process in which the transmitter is cotransported with three sodium ions and one proton, followed by countertransport of a potassium ion. Produced by recombinant technology in Rabbit hosts and purified by Protein A affinity chromatography, this Rabbit IgG antibody is reactive against Human samples.
This antibody is suitable for WB and IHC applications. It has been validated by WB analysis of Human heart,?Human liver and IHC analysis of Human kidney, Human oligodendroglioma. The target is localized to the cell membrane, recycling endosome membrane.
![Anti-EAAT3 [R09-9X1] Monoclonal Antibody (AGMB01408)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/images/stencil/590x590/products/272697/679958/anti-eaat3-r09-9x1-monoclonal-antibody-agmb01408__43884.1773040581.jpg?c=2 "Anti-EAAT3 [R09-9X1] Monoclonal Antibody (AGMB01408)")
