14-3-3 beta / YWHAB is a member of the 14-3-3 proteins family. 14-3-3 proteins are a family of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are found in synapses and neuronal cytoplasm. In mice, seven different forms have been discovered. 14-3-3 proteins were initially identified as adaptor proteins that bind to phosphoserine-containing motifs. The 14-3-3 proteins' structural motifs, as well as their possible roles, are now known to have a wide range of functional relevance. 14-3-3 beta / YWHAB is found in both plants and mammals, and this protein is 100% homologous to the mouse counterpart. YWHAB interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting a role in multiple biochemical processes linked to signal transduction, such as cell division and insulin sensitivity regulation. Small cell lung cancer has also been linked to YWHAB. YWHAB binding inhibits RSK1 activity by regulating signal specificity, and the 14-3-3beta-RSK1 complex's association/dissociation is likely to be significant for mitogen-induced RSK1 activation. Human 14-3-3 beta/YWHAB Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human 14-3-3 beta/YWHAB Recombinant Protein (RPES0464)
Product Code:
RPES0464
Size:
50µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
GW128,HEL-S-1,HS1,KCIP-1,YWHAA
Accession:
NP_003395.1
Sequence:
Met 1-Asn 246
Fusion tag:
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human YWHAB (NP_003395.1) (Met 1-Asn 246) was expressed, with two additional amino acids (Gly & Pro) at the N-terminus.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
