The alpha-Synuclein (alpha-Syn) protein, abbreviated as NACP or SNCA, exists in two structural forms: a helix-rich, membrane-bound form with the Nand C-terminal sections of alpha-synuclein that are firmly linked to membranes, and a disordered, cytosolic species The majority of Synuclein is located in the presynaptic terminals, both free and membrane-bound. The SNCA is highly concentrated in the nucleus of neurons. In the olfactory bulb, hippocampus, striatum, and thalamus, alpha-Synuclein was highly expressed in the mitochondria while the cytosolic alpha-Synuclein was also plentiful. In pathological states associated with Lewy bodies, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, the unstructured soluble form of alpha-synuclein may aggregate to form insoluble fibrils. Mitochondrial damage and SNCA abnormality are two significant abnormalities in the brain of persons with Parkinson's disease (PD). In addition, alpha-synuclein is present in all forms of Parkinson's disease and diffuse Lewy body disease. Human Alpha-Synuclein/SNCA Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human Alpha-Synuclein/SNCA Recombinant Protein (RPES3686)
A DNA sequence encoding the mature form of human SNCA isoform 1 (P37840-1) (Met 1-Ala 140) was expressed and purified.
Purity:
> 97 % as determined by reducing SDS-PAGE.
Mol Mass:
14.5 kDa
AP Mol Mass:
19 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
