Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. The protein is most abundant in the central nervous system, where it's mostly found in astrocytes. PEA15 levels are directly related to tumour cell growth and progression. The protein PEA15 is overexpressed in breast cancers, gliomas, and type 2 diabetes. PEA15 inhibits the Ras-mediated inhibition of integrin activation, and it modulates the ERK MAP kinase pathway. RPS6KA3's function is inhibited by PEA15 by keeping it in the cytoplasm. PEA15 inhibits both TNFRSF6 and TNFRSF1A-mediated CASP8 activity and apoptosis. PEA15 protein expression is now recognized as a prognostic indicator for ovarian cancer. Human PEA15 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human PEA15 Recombinant Protein (RPES3043)
Product Code:
RPES3043
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Astrocytic Phosphoprotein PEA-15, 15 kDa Phosphoprotein Enriched in Astrocytes, Phosphoprotein Enriched in Diabetes, PED, PEA15
Accession:
Q15121
Sequence:
Met 1-Ala130
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Phosphoprotein Enriched in Astrocytes of 15 kDa is produced by our E.coli expression system and the target gene encoding Met1-Ala130 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
15.3 kDa
AP Mol Mass:
12-16 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
