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Human CD155/PVR/NECL5 Recombinant Protein (RPES0441)

SKU:
RPES0441
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology
€188
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Description

system_update_altDatasheet

Human CD155/PVR/NECL5 Recombinant Protein

Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (?; β; ?; and ?) with identical extracellular domains.