CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors; associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs; 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions; and cell survival during differentiation of the mESC into terminally differentiated cell types.
Product Name:
Human CDK2AP2 Recombinant Protein (RPES4902)
Product Code:
RPES4902
Size:
100 µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Cyclin-dependent kinase 2-associated protein 2,CDK2-associated protein 2,DOC-1-related protein,DOC-1R,CDK2AP2,DOC1R,p14
Accession:
O75956
Sequence:
Met 1-Thr 126
Fusion tag:
C-His
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human CDK2AP2 (O75956) (Met 1-Thr 126) was fused with a polyhistidine tag at the C-terminus.
Purity:
> 78 %(the upper band)+17 %(the lower band) as determined by reducing SDS-PAGE.
Mol Mass:
14.5 kDa
AP Mol Mass:
18 and 12 kDa
Formulation:
Lyophilized from sterile PBS; 15% glycerol; pH 7.5
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
