CDO (CAMrelated/down-regulatedby oncogenes) is a member of the Immunoglubulin (Ig) superfamily, Ig/Fibronectin (FN)type III repeat family of cell surface proteins. Human CDO is a type I transmembrane (TM) glycoprotein. It is synthesized as a 1287 amino acid (aa) precursorthat contains a 25 aa signal sequence, a 938 aa extracellular domain (ECD), a 21 aa TM segment and a 303 aa cytoplasmic region. The ECD contains five C2-typeIglikedomains, followed by three FN type III repeats. The ECD of human CDO is 85% aa identical to mouse CDO ECD.CDO is found on muscle precursor and neural progenitor cells of the embryo. It likely promotes muscle differentiation, and contributes to axon guidance andneuronal patterning.
Product Name:
Human CDO/CDON Recombinant Protein (RPES3555)
Product Code:
RPES3555
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Cell adhesion molecule-related/down-regulated by oncogenes, CDON, CDO
Accession:
Q4KMG0
Sequence:
Asp26-Pro943
Fusion tag:
C-His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human CDO is produced by our Mammalian expression system and the target gene encoding Asp26-Pro943 is expressed with a 6His tag at the C-terminus.
Purity:
> 85% as determined by reducing SDS-PAGE.
Mol Mass:
100.4 kDa
AP Mol Mass:
120-135 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
