Human Endoglin/CD105 Recombinant Protein (RPES1401)

SKU:
RPES1401
Product type:
Recombinant Protein
Host species:
HEK293 Cells
Reactivity:
Human
€402

Description

ELISA Kit Technical Manual

Recombinant Human Endoglin/CD105 Protein (His Tag)

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Background:Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-? superfamily ligands, endoglin binds TGF-?1 and TGF-?3 with high affinity not by itself but by associating with TGF-? type I I receptor (T?RII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.
Name:Recombinant Human Endoglin/CD105 Protein (His Tag)
Size:20µg
Assay Genie SKU:RPES1401
Synonyms:Endoglin; END; CD105; ENG;HHT1;ORW1
Species:Human
Expression host:HEK293 Cells
Sequence:Met 1-Gly 586
Accession:NP_001108225.1
Mol Mass:62.3 kDa
AP Mol Mass:80-90 kDa
Tag:C-His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4
Reconstitution:Please refer to the printed manual for detailed information.