Fc Receptor-Like Protein 1 (FCRL1) is a single-pass type I membrane protein that may function as an activating coreceptor in B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It can be detected in the spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. It is specifically expressed by mature B lineage cells with higher expression at the protein level in naive B cells compared to memory B cells. FCRL1 contains three extracellular C2-like immunoglobulin domains, a transmembrane domain, and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs and may play a role in the regulation of cancer cell growth.
Product Name:
Human FCRL1 Recombinant Protein (RPES2774)
Product Code:
RPES2774
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Fc Receptor-Like Protein 1, FcR-Like Protein 1, FcRL1, Fc Receptor Homolog 1, FcRH1, IFGP Family Protein 1, hIFGP1, Immune Receptor Translocation-Associated Protein 5, CD307a, FCRL1, FCRH1, IFGP1, IRTA5
Accession:
Q96LA6
Sequence:
Ala17-Asn303
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Fc Receptor-Like Protein 1 is produced by our Mammalian expression system and the target gene encoding Ala17-Asn303 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
32.2 kDa
AP Mol Mass:
39-50 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
