Recombinant Human FGF18 Protein (His Tag) (RPES8946)
Fibroblast Growth Factor 18 (FGF-18) is a 20 kDa protein that plays an important role in skeletal development and bone homeostasis . Mature human FGF-18 shares 99% amino acid sequence identity with mouse and rat FGF-18 . It is expressed in embryonic somites and the neural fold, adult lung, cerebellar and hippocampal neurons, hair follicle root sheath cells, and osteogenic mesenchymal cells . FGF-18 binds to FGF R2c, FGF R3c as well as the Golgi protein GLG1 and induces the proliferation of astrocytes and microglia, vascular endothelial cells, dermal fibroblasts, papilla cells, and keratinocytes . FGF-18 is required for normal skeletal development . It recruits osteoclasts and osteoblasts to the growth plate, promotes osteoclast formation and function, inhibits osteoblast differentiation, promotes skeletal vascularization, and induces chondrocyte hypertrophy and cartilage matrix formation.
Product Name:
Recombinant Human FGF18 Protein (His Tag)
SKU:
RPES8946
Size:
20μg, 100μg, 500μg, 1mg
Species:
Human
Synonyms:
FGFI, zFGF5
Tag:
C-His
Sequence:
Val31-Ala207
Expression Host:
E.coli
Accession:
O76093
Purity:
> 95% as determined by reducing SDS-PAGE.
Endotoxin:
< 10 EU/mg of the protein as determined by the LAL method
Bio-Activity:
Not validated for activity
Form:
Lyophilized powder
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol.
Storage:
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
