The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. The FGF family members have significant mitogenic and cell survival activities, and are involved in a wide range of biological processes, including embryonic development, cellular growth, morphogenesis, tissue healing, tumor growth and invasion. The protein is an androgen that helps to promote mammary tumor cell growth. Elevated expression of this gene has been linked to tumor development and angiogenesis. This gene is only expressed in the adult testes and ovaries. The expression time and pattern suggest that this gene is involved in embryonic epithelial development. Midbrain and limb development, organogenesis, embryo gastrulation, and left-right axis determination are among the functions of the mouse and chicken homologues. Four transcript variants are produced as a consequence of the alternative splicing of this gene. Human FGF8a/FGF-8a Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human FGF8a/FGF-8a Recombinant Protein (RPES3095)
Product Code:
RPES3095
Size:
50µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
AIGF,FGF-8,HBGF-8,HH6,KAL6
Accession:
NP_149355.1
Sequence:
Gln23-Arg204
Fusion tag:
Activity:
Measured in a cell proliferation assay using BALB/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.8-3.3 µg/mL.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human FGF8a (NP_149355.1) (Gln23-Arg204) was expressed with an initial Met.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
21.3 kDa
Formulation:
Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.5
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
