Hepassocin; also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1); is a liver-specific secreted protein belonging to the fibronogen superfamily; whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3 .
Product Name:
Human FGL1 Recombinant Protein (RPES2737)
Product Code:
RPES2737
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Fibrinogen-like protein 1, FGL1, HP-041, Hepassocin, HFREP-1, LFIRE-1
Accession:
Q08830
Sequence:
Leu23-Ile312
Fusion tag:
C-mFc
Activity:
Immobilized Human LAG-3(Cat: PKSH033596) at 5µg/ml(100 ?l/well) can bind Human FGL1-Fc. The ED50 of Human FGL1-Fc is 2.1 ug/ml.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Fibrinogen-like Protein 1 is produced by our Mammalian expression system and the target gene encoding Leu23-Ile312(Trehalose) is expressed with a mFc tag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
60.6 kDa
AP Mol Mass:
60-65 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS; 5% Thehalose; pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
