Recombinant Human Galanin/GAL Protein (Fc Tag) (RPES1695)

SKU:
RPES1695
€402

Description

ELISA Kit Technical Manual

Recombinant Human Galanin/GAL Protein (Fc Tag)

Background:The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD180, also known as RP105, is a B-cell surface molecule belonging to the family of pathogen receptors, Toll-like receptors (TLR). CD180 has an extracellular leucine-rich repeats and a short cytoplasmic tail. CD180 / RP105 interact with an extracellular molecule named MD1 and then together form the cell surface receptor complex RP105 / MD1 which induces B-cell activation in humans and mice, leading to proliferation and up-regulation of a costimulatory molecule, B7.2 / CD86. CD180 / RP105 also has a role in LPS response because B cells lacking RP105 show hyporesponsiveness to LPS.
Name:Recombinant Human Galanin/GAL Protein (Fc Tag)
Size:20µg
Assay Genie SKU:RPES1695
Synonyms:GAL-GMAP;GALN;GLNN;GMAP
Species:Human
Expression host:HEK293 Cells
Sequence:Met 1-Ser123
Accession:P22466
Mol Mass:38.5 kDa
AP Mol Mass:43 kDa
Tag:C-Fc
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg of the protein as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:Galanin: Contracts smooth muscle of the gastrointestinal and genitourinary tract, regulates growth hormone release, modulates insulin release, and may be involved in the control of adrenal secretion. Belongs to the galanin family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: Golgi apparatus; extracellular space; cell soma; extracellular region; secretory granule

Molecular Function:type 3 galanin receptor binding; neuropeptide hormone activity; protein binding; type 2 galanin receptor binding; type 1 galanin receptor binding

Biological Process: response to drug; nervous system development; positive regulation of cortisol secretion; positive regulation of apoptosis; positive regulation of catagen; negative regulation of lymphocyte proliferation; response to insulin stimulus; cAMP-mediated signaling; response to estrogen stimulus; neuropeptide signaling pathway; insulin secretion; regulation of glucocorticoid metabolic process; feeding behavior; positive regulation of transcription from RNA polymerase II promoter; inflammatory response

Disease: Epilepsy, Familial Temporal Lobe, 8

NCBI Summary:Galanin is small neuropeptide that functions as a cellular messenger within the central and peripheral nervous systems, modulating diverse physiologic functions (Mechenthaler, 2008 [PubMed 18500643]).[supplied by OMIM, Jan 2009]
UniProt Code:P22466
NCBI GenInfo Identifier:2506449
NCBI Gene ID:51083
NCBI Accession:P22466.3
UniProt Secondary Accession:P22466,Q14413,
UniProt Related Accession:P22466
Molecular Weight:13,302 Da
NCBI Full Name:Galanin peptides
NCBI Synonym Full Names:galanin/GMAP prepropeptide
NCBI Official Symbol:GAL  
NCBI Official Synonym Symbols:GALN; GLNN; GMAP; GAL-GMAP  
NCBI Protein Information:galanin peptides; galanin prepropeptide; galanin-message-associated peptide; galanin-related peptide
UniProt Protein Name:Galanin peptides
Protein Family:Galanin
UniProt Gene Name:GAL  
UniProt Entry Name:GALA_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
HEK293 Cells
Reactivity:
Human
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