Hyaluronan-binding protein 2?HABP2? is an extracellular serine protease which binds hyaluronic acid. It secreted as an inactive single-chain precursor and is then activated to a heterodimeric form, which consists of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond. HABP2 is involved in cell adhesion, it can cleave the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' , but not the gamma-chain of fibrinogen. As a result of this, it does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator to the active two chain form, activates coagulation factor VII.
Product Name:
Human HABP2 Recombinant Protein (RPES1870)
Product Code:
RPES1870
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Hyaluronan-binding protein 2, Factor VII-activating protease, Factor seven-activating protease, Hepatocyte growth factor activator-like protein, Plasma hyaluronan-binding protein
Accession:
Q14520
Sequence:
Met1-Gln279
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Hyaluronan-binding Protein 2 is produced by our Mammalian expression system and the target gene encoding Met1-Gln279 is expressed with a 6His tag at the C-terminus.
Purity:
> 90 % as determined by SDS-PAGE
Mol Mass:
36.2 kDa
AP Mol Mass:
38 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4 .
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
