Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes are master control regulators of developmental programs including embryonic and adult hematopoiesis. Multiple HOX genes, including HOXB4, are highly expressed in the hematopoietic stem cells (HSC) compartment. HOXB4 gene can act in opposite ways when expressed by different cells, promoting the proliferation of stem cells whilst activating the apoptotic pathway in some embryonic structures. The protein HOXB4, as a homeodomain transcription factor, has been shown to be an important regulator of stem cell renewal and hematopoiesis. Incellular or ectopic expression of HOXB4 expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Product Name:
Human HOXB4 Recombinant Protein (RPES1043)
Product Code:
RPES1043
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Homeobox protein Hox-B4, Homeobox protein Hox-2.6, Homeobox protein Hox-2F, HOXB4, HOX2F
Accession:
P17483
Sequence:
Met1-Leu251
Fusion tag:
N-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Homeobox protein B4 is produced by our E.coli expression system and the target gene encoding Met1-Leu251 is expressed with a 6His tag at the N-terminus.
Purity:
> 95 % as determined by SDS-PAGE
Mol Mass:
29.8 kDa
AP Mol Mass:
36 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 4mM HCl.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
