Recombinant Human ICAM-2/CD102 Protein (His Tag) (RPES1949)

SKU:
RPES1949
€68

Description

ELISA Kit Technical Manual

Recombinant Human ICAM-2/CD102 Protein (His Tag)

Background:ICAM-2 is a 55-65 kD transmembrane glycoprotein possessing 2 extracellular Ig domains, a single transmembrane domain, and a short 26-amino acid cytoplasmic domain. ICAM-2 is expressed on most leukocytes, and is strongly expressed on vascular endothelial cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.
Name:Recombinant Human ICAM-2/CD102 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES1949
Synonyms:Intercellular Adhesion Molecule 2; ICAM-2; CD102; ICAM2
Species:Human
Expression host:Human Cells
Sequence:Lys25-Gln223
Accession:P13598
Mol Mass:23.13 kDa
AP Mol Mass:55 kDa
Tag:C-His
Purity:> 95% as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per ?g as determined by the LAL method.
Storage:Lyophilized protein should be stored at < -20'C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, 2mM CaCl2, 2mM MgCl2, 5% Threhalose, pH 7.2.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:ICAM2: ICAM proteins are ligands for the leukocyte adhesion protein LFA (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-dependent cell adhesion. It mediates adhesive interactions important for antigen- specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Belongs to the immunoglobulin superfamily. ICAM family.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: membrane; integral to plasma membrane; plasma membrane; uropod

Molecular Function:integrin binding

Biological Process: extracellular matrix organization and biogenesis; cell-cell adhesion; regulation of immune response; cell adhesion

NCBI Summary:The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA protein. This protein may play a role in lymphocyte recirculation by blocking LFA-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P13598
NCBI GenInfo Identifier:115502404
NCBI Gene ID:3384
NCBI Accession:P13598.2
UniProt Secondary Accession:P13598,Q14600,
UniProt Related Accession:P13598
Molecular Weight:30,654 Da
NCBI Full Name:Intercellular adhesion molecule 2
NCBI Synonym Full Names:intercellular adhesion molecule 2
NCBI Official Symbol:ICAM2  
NCBI Official Synonym Symbols:CD102  
NCBI Protein Information:intercellular adhesion molecule 2; ICAM-2
UniProt Protein Name:Intercellular adhesion molecule 2
UniProt Synonym Protein Names:CD_antigen: CD102
Protein Family:Intercellular adhesion molecule
UniProt Gene Name:ICAM2  
UniProt Entry Name:ICAM2_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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