Interleukin 1 receptor, type I (IL-1R1) is a kind of interleukin receptor. It is also known as CD121a (Cluster of Differentiation 121a). IL-1R1/CD121a is a cytokine receptor in the interleukin 1 receptor family. Interleukin 1 receptor, type I (IL1R1/IL1RA) is a protein that binds to interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA). IL-1R1/CD121a is an important mediator involved in many cytokine induced immune and inflammatory responses. The protein has been studied pharmacologically and molecularly in the mouse brain. The wound is closed by spindle-shaped astrocytes, which separate healthy from damaged neural tissue. The shape change and subsequent repair processes are IL-1 beta activity-dependent, acting through the IL-1 type 1 receptor (IL-1R1), as co-application of the IL-1 type 1 receptor antagonist protein (IL-1ra) blocks IL-1 beta induced effects. During the first hours following LPS stimulation, a slight rise in IL-1R AcP and IL-1R1 was observed in the spleen. In conclusion, IL-1R AcP mRNA is present in the brain and other tissues where IL-1R1/CD121a transcripts are found. However, the regulation of its expression is distinct from IL-1R1/CD121a. The high level of expression and the lack of regulation of IL-1R AcP transcripts in the brain under inflammatory conditions suggest that the protein might be constitutively expressed in excess. Human IL1R1/CD121a Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human IL1R1/CD121a Recombinant Protein (RPES1656)
Product Code:
RPES1656
Size:
100 µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
CD121A,D2S1473,IL-1 RI,IL-1R-alpha,IL-1R1,IL1R,IL1RA,P80,Interleukin-1 receptor type 1, IL-1R-1, IL-1RT-1, IL-1RT1, CD121 antigen-like family member A, Interleukin-1 receptor alpha, IL-1R-alpha
Accession:
NP_000868.1
Sequence:
Met 1-Thr332
Endotoxin:
<1.0 EU per µg of the protein as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human IL1R1 (NP_000868.1) (Met1-Thr332) was expressed with five amino acids (DDDDK) at the C-terminus was expressed and purified.
Purity:
> 90 % as determined by reducing SDS-PAGE.
Mol Mass:
36.8 kDa
AP Mol Mass:
56 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
