Lipopolysaccharide binding protein (LBP) is a plasma protein, belongs to a member of structurally and functionally related proteins which includes bactericidal permeability-increasing protein (BPI), plasma cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP). It is involved in the acute-phase immunologic response to gram-negative bacterial infections. In cooperation with BPI. LBP binds LPS and interacts with the CD14 receptor, most likely playing a role in regulating LPS-dependent monocyte responses. Studies suggest that LBP is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. Finally, t The LBP gene is found on chromosome 20, directly downstream of the BPI gene.
Product Name:
Human LBP Recombinant Protein (RPES3788)
Product Code:
RPES3788
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Lipopolysaccharide-Binding Protein, LBP,BPIFD2
Accession:
NP_004130.2
Sequence:
Ala26-Val481
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Lipopolysaccharide-Binding Protein is produced by our Mammalian expression system and the target gene encoding Ala26-Val481 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
52.0 kDa
AP Mol Mass:
64 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.2.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
