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Human LDLR Recombinant Protein (RPES4265)

SKU:
RPES4265
Product Type:
Recombinant Protein
Species:
Human
€236
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Description

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Human LDLR Recombinant Protein

Low-Density Lipoprotein Receptor (LDLR) is a transmembrane glycoprotein that plays a critical role in cholesterol homeostasis. LDLR mediates blood cholesterol level by interacting with lipoprotein particles like LDL and VLDL. The extracellular domain of LDLR contains LDL receptor type A (ligand-binding) modules (LA repeats), epidermal growth factor-like modules, and LY repeats containing the YWTD consensus motif that are important in binding and releasing of ApoB-100 and ApoE in lipoprotein particles. The C terminal domain of LDLR inside the cell is required for the receptor internalization. Loss of function mutations in the LDLR gene causes Familial Hypercholesterolemia (FH).

Product Name:Human LDLR Recombinant Protein (RPES4265)
Product Code:RPES4265
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Low-Density Lipoprotein Receptor, LDL Receptor, LDLR,FH,FHC,LDL R,LDL Receptor,LDLCQ2
Accession:NP_000518.1
Sequence:Ala22-Arg788
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Low-Density Lipoprotein Receptor is produced by our Mammalian expression system and the target gene encoding Ala22-Arg788 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:84.8 kDa
AP Mol Mass:99-135 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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