Human MAN1B1 Recombinant Protein (RPES3201)
- SKU:
- RPES3201
- Product Type:
- Recombinant Protein
- Species:
- Human
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Description
system_update_altDatasheet
Human MAN1B1 Recombinant Protein
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-?-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
| Product Name: | Human MAN1B1 Recombinant Protein (RPES3201) |
| Product Code: | RPES3201 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-Alpha-Mannosidase, ER Alpha-1,2-Mannosidase, ER Mannosidase 1, ERMan1, Man9GlcNAc2-Specific-Processing Alpha-Mannosidase, Mannosidase Alpha Class 1B Member 1, MAN1B1 |
| Accession: | Q9UKM7 |
| Sequence: | Asp106-Ala699 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-?-Mannosidase/MAN1B1 is produced by our Mammalian expression system and the target gene encoding Asp106-Ala699 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 68.7 kDa |
| AP Mol Mass: | 68 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 50mM TrisHCL,10mM reduced Glutathione,pH 8.0. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
