USP46 belongs to the peptidase C19 family; USP12/USP46 subfamily. Deubiquitinating enzymes (DUBs) are a large group of proteases which are also commonly referred to as deubiquitinating peptidases; deubiquitinating isopeptidases; deubiquitinases; ubiquitin proteases; ubiquitin hydrolyases; ubiquitin isopeptidases; or Dubs. By cleaving ubiquitin-protein bonds, they regulate ubiquitin-dependent metabolic pathways. They may also be used to regulate the ubiquitin system in a negative or positive manner. They are also involved in the processing of ubiquitin precursors, protein ubiquitination, and the dismantling of inhibitory ubiquitin chains. The Usp46 protein is a deubiquitinating enzyme that has an effect on behavior; it's possible that it controls GABA activity. It may help to regulate GAD1/GAD67 deubiquitination by acting as a modulator. The enzyme USP46 has little deubiquitinating activity on its own, and it requires the assistance of WDR48 to be active, which suggests that it is not involved in monoubiquitinated FANCD2 deubiquitination. Human/Mouse USP46 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human/Mouse USP46 Recombinant Protein (RPES1653)
Product Code:
RPES1653
Size:
20µg
Species:
Human
Expressed Host:
Baculovirus-Insect Cells
Synonyms:
USP46
Accession:
NP_808229.1
Sequence:
Met 1-Glu366
Fusion tag:
N-SUMO
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human USP46 [(Identical to the mouse USP46 (NP_808229.1)] (Met1-Glu366) was expressed and purified.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
