Human Protachykinin/TAC1 Recombinant Protein (RPES3005)

SKU:
RPES3005
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
€361

Description

ELISA Kit Technical Manual

Recombinant Human Protachykinin/TAC1 Protein (His Tag)

Background:Protachykinin(TAC1) is a secreted protein and belongs to the tachykinin family. TAC1 is encoded by the TAC1 gene. This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues.
Name:Recombinant Human Protachykinin/TAC1 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES3005
Synonyms:Protachykinin;PPT;TAC1
Species:Human
Expression host:E.coli
Sequence:Glu20-Arg129
Accession:P20366
Mol Mass:15.2 kDa
AP Mol Mass:18 kDa
Tag:N-6His
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation:Supplied as a 0.2 um filtered solution of 20mM Tris,150mM NaCl,pH 8.0(10% glycerol 2M Urea).
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:TAC1: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: extracellular space; cell soma; axon; extracellular region; plasma membrane

Molecular Function:protein binding; substance P receptor binding

Biological Process: tachykinin signaling pathway; negative regulation of heart rate; insemination; response to hormone stimulus; response to morphine; response to lipopolysaccharide; response to pain; sensory perception of pain; positive regulation of saliva secretion; synaptic transmission; elevation of cytosolic calcium ion concentration; cell-cell signaling; positive regulation of acute inflammatory response; positive regulation of lymphocyte proliferation; neuropeptide signaling pathway; regulation of blood pressure; positive regulation of stress fiber formation; positive regulation of action potential; inflammatory response; associative learning; detection of abiotic stimulus; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, GABAergic; positive regulation of ossification; long-term memory

NCBI Summary:This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
UniProt Code:P20366
NCBI GenInfo Identifier:135886
NCBI Gene ID:6863
NCBI Accession:P20366.1
UniProt Related Accession:P20366
Molecular Weight:
NCBI Full Name:Protachykinin
NCBI Synonym Full Names:tachykinin precursor 1
NCBI Official Symbol:TAC1  
NCBI Official Synonym Symbols:NK2; NPK; NKNA; TAC2; Hs.2563  
NCBI Protein Information:protachykinin
UniProt Protein Name:Protachykinin
UniProt Synonym Protein Names:PPTCleaved into the following 5 chains:Substance P; Neurokinin A; NKAAlternative name(s):Neuromedin L; Substance K
Protein Family:Splenin
UniProt Gene Name:TAC1  
UniProt Entry Name:TKN1_HUMAN