S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-handmotifs. The S100 proteins are cell- and tissue-specific, with many intra-and extracellular functions through interactions with unique target proteins. Astrocyte S100A16 expression was determined to be specific. In response to Ca(2+) stimulation, the S100A16 protein was discovered to accumulate in nucleoli and migrate to the cytoplasm. The homodimeric form of human S100A16 in the apo state has been determined both in the solid and solution states, resulting in a high degree of correspondence between the structures. In the calcium(II)-bound form, the homodimeric solution structure of human S100A16 was also determined. The results of the immunoprecipitation analysis indicated that S100A16 could physically interact with tumor suppress or protein p53, both of which are known adipogenic inhibitors. The expression of p53-responsive genes may be reduced or activated by overexpression or RNA interference-initiated reduction of S100A16. The S100a16 protein is a newly discovered adipogenesis-optimizing factor. Human S100A16/S100F Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human S100A16/S100F Recombinant Protein (RPES0210)
Product Code:
RPES0210
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
SLAM Family Member 6, Activating NK Receptor, NK-T-B-Antigen, NTB-A, CD352, SLAMF6, KALI, Ly108, NTBA, SF2000
Accession:
Q96FQ6
Sequence:
Met1-Ser103
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human S100A16 is produced by our E.coli expression system and the target gene encoding Met1-Ser103 is expressed.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
11.8 kDa
AP Mol Mass:
22 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM Tris; 500mM NaCl; pH8.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
