SLAM family member 6 (Activating NK receptor; NK-T-B-antigen; NTB-A; SLAMF6; KALI and Ly108) is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. The SMAMF6 has one Ig-like (immunoglobulin-like) domain. SLAMF6 is expressed by all (resting and activated) natural killer cells (NK); T- and B-lymphocytes. SLAMF6 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 is a homodimer. SLAMF6 interacts with PTN6 and; upon phosphorylation; with PTN11 and SH2D1A/SAP. Tyrosine phosphorylation of SLAMF6 induces binding to the Src homology 2 domain-containing protein (SH2D1A) and SH2 domain-containing phosphatases (SHPs). SLAMF6 may function as a coreceptor in the process of NK cell activation. SLAMF6 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Human SLAMF6/Ly108 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Human SLAMF6/Ly108 Recombinant Protein (RPES4544)
Product Code:
RPES4544
Size:
50µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
SLAM Family Member 6, Activating NK Receptor, NK-T-B-Antigen, NTB-A, CD352, SLAMF6, KALI, Ly108, NTBA, SF2000
Accession:
Q96DU3-1
Sequence:
Met 1-Met226
Fusion tag:
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the human SLAMF6 (Q96DU3-1)(Met1-Met226) was expressed with six amino acids (LEVLFQ) at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
23.9 kDa
AP Mol Mass:
37-43 kDa
Formulation:
Lyophilized from sterile PBS; pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
