Sulfotransferase family cytosolic 1B member 1; also known as Sulfotransferase 1B1; Sulfotransferase 1B2; Thyroid hormone sulfotransferase; SULT1B1 and ST1B2; is a cytoplasm protein which belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones; neurotransmitters; drugs; and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1B1 is highly expressed in the liver; peripheral blood leukocytes; colon (mucosal lining); small intestine (jejunum) and spleen. A lesser expression of SULT1B1 was observed in the lung; placenta and thymus. SULT1B1 catalyzes the sulfate conjugation of many hormones; neurotransmitters; drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds; and therefore their renal excretion; but it can also result in bioactivation to form active metabolites. SULT1B1 sulfates dopamine; small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones; including 3;3'-diiodothyronine; triidothyronine; reverse triiodothyronine and thyroxine.
Product Name:
Human SULT1B1 Recombinant Protein (RPES0872)
Product Code:
RPES0872
Size:
50 µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Sulfotransferase Family Cytosolic 1B Member 1, ST1B1, Sulfotransferase 1B1, Sulfotransferase 1B2, ST1B2, Thyroid Hormone Sulfotransferase, SULT1B1, ST1B2, SULT1B2
Accession:
NP_055280.2
Sequence:
Leu 2-Ile 296
Fusion tag:
N-His
Activity:
Measured by its ability to transfer sulfate from PAPS to 1-Napthol.The specific activity is > 40 pmoles/min/µg.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human SULT1B1 (NP_055280.2) (Leu 2-Ile 296) was expressed; with a N-terminal polyhistidine tag.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
35.7 kDa
AP Mol Mass:
34 kDa
Formulation:
Lyophilized from sterile 20mM Tris; 0.1 M NaCl; 10% glycerol; 1mM DTT; pH 8.0
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
