Sulfotransferase family cytosolic 2B member 1; also known as Sulfotransferase 2B1; ST2B1; Alcohol sulfotransferase; Hydroxysteroid sulfotransferase 2; SULT2B1 and HSST2; is a cytoplasm protein which belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies; SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta; prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones; neurotransmitters; drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds; and therefore their renal excretion; but it can also result in bioactivation to form active metabolites. SULT2B1 sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol. The two SULT2B1 isoforms; SULT2B1a and SULT2B1b; are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol; whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation.
Product Name:
Human SULT2B1 Recombinant Protein (RPES1594)
Product Code:
RPES1594
Size:
50 µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Sulfotransferase Family Cytosolic 2B Member 1, ST2B1, Sulfotransferase 2B1, Alcohol Sulfotransferase, Hydroxysteroid Sulfotransferase 2, SULT2B1, HSST2
Accession:
NP_004596.2
Sequence:
Asp 2-Ser 365
Fusion tag:
N-His
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the human SULT2B1 (NP_004596.2) (Asp 2-Ser 365) was expressed; with a N-terminal polyhistidine tag.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
